New study finds 4 OCD related genes

A new study just out in Nature Communications:

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Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly associated genes, validated in a larger cohort. NRXN1 and HTR2A are enriched for coding variants altering postsynaptic protein-binding domains. CTTNBP2 (synapse maintenance) and REEP3 (vesicle trafficking) are enriched for regulatory variants, of which at least six (35%) alter transcription factor-DNA binding in neuroblastoma cells. NRXN1 achieves genome-wide significance (p = 6.37 × 10−11) when we include 33,370 population-matched controls. Our findings suggest synaptic adhesion as a key component in compulsive behaviors, and show that targeted sequencing plus functional annotation can identify potentially causative variants, even when genomic data are limited.

New Scientist reported about the study and there is a short video here:

 

World Congress of Psychiatric Genetics in Orlando

The 25th World Congress of Psychiatric Genetics just ended in Orlando. Evelyn Hagen Andersson, Julia Boberg and Christian Rück represented our group.

There was huge interest in the poster that Evelyn presented on the association of genetic load for ADHD and Autism and outcome of CBT for depression in a sample of 971 patients. The conference also included a presentation by Andreas Forster on the largest genome-wide study of panic disorder where 400+ cases from our data collection where included. We are happy to soon be part of several work groups of the Psychiatric Genomics Consortium. The future in psychiatric genetics is clearly collaborative.

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Evelyn Hagen Andersson in action. 

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Pat Sullivan being starstruck. 

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Panic GWAS findings

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Panic GWAS contributors. 

Congratulations, Doctor Volen Ivanov!

Volen Ivanov publicly defended his thesis “Never let go! : the etiology, clinical presentation and treatment of hoarding disorder” last Friday. The defense and opposition by Professor Kiara Timpano was a true celebration of science. Congratulation Volen to your well-deserved PhD!

 

 

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Volen Ivanov, PhD!

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Volen with his proud supervisors Christian Rück, Eva Serlachius, David Mataix-Cols!

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Dissertation committee Sten-Åke Stenberg, Karin Wirdefeldt and Maria Tillfors.

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Opponent and Respondent. 

Chris LaLima’s superduper dissertation

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Man of the day

Christopher LaLima, psychologist from Hofstra University who was with us in our group in 2015-16 very successfully defended his thesis “Therapist-Guided, Internet-Based Cognitive Behavioral Therapy for Body Dysmorphic Disorder – English Version (BDD-NET): A Feasibility Study” today at Hofstra University, NY. Congrats Chris! Chris was even nominated for the H. Alan Robinson Outstanding Doctoral Dissertation Award! Good luck! Skärmavbild 2017-08-28 kl. 22.05.06

 

 

Doctor Jesper Enander defended his thesis!

Jesper Enander today received his PhD after successfully defending his thesis today. Congratulations Jesper!

 

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Jesper (the tallest) surrounded by his supervisors. To the left the opponent Prof Ulrike Buhlmann being distracted by Prof Jerker Hetta from the examination board.

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The examination board: Klaas Wijma, Linköping University, Jerker Hetta and Kalle Lundgren, KI.

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Showtime.

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It’s done.

Manuel Mattheisen joins our group

Our collaborator Manuel Mattheisen, Associate Professor at Århus University, is now officially affiliated to Karolinska Institutet and our group.  He studied medicine at the University in Bonn and went on to be a research follow at Harvard Medical School before moving to Denmark. We are fortunate to enjoy his deep expertise in genetical methods. Check out his quite spectacular publication list here.

Manuel