John Wallert receives grant

We are very grateful to announce that the Söderström-König Foundation has awarded John Wallert with a grant of 350 000 SEK for the project “PRiMED: Predicting Response after cognitive behaviour therapy in MEntal Disorders using multimodal data and machine learning”. We are excited to use this funding to continue our work at building advanced prediction models to be used as decision support in future clinical psychiatry.

Welcoming Elin Lindsäter

We are happy to announce that Elin Lindsäter starts a post doc today in our group. She is a psychologist and PhD and has extensive experience working with and researching stress and exhaustion. Our group is now expanding into this field, supported by a grant from the Swedish Research Council. Welcome Elin!

Elin Lindsäter | Medarbetare

Half-time seminar: Long Long Chen

Today Long Long Chen, psychiatrist and PhD student in our group, passed his half-time control towards his PhD with flying colors. Diana Djurfeldt is his main supervisor, with Cynthia Bulik and Christian Rück co-supervising. The titel of his PhD project is “Advances in studying OCD – from next-generation sequencing to deep brain stimulation”. The advisory board, Lisa Ekselius, Uppsala University, Björn Andersson and Rochellys Diaz Heijtz, KI provided very valuable feedback.

Long-Long, master of Zoom.

Welcoming John Wallert

We are happy to announce that John Wallert just has started a full-time post doc in our group. He is a psychologist who just received his PhD from Uppsala University. You can read his dissertation here. His expertise in predictive and causal modeling, including machine learning methods, will now be a welcome addition to our team where he will be involved on projects trying to forecast who improves after treatment.

Ny studie: penisstudien.se och vulvastudien.se

 

På senare tid har det uppmärksammats att många människor är missnöjda med utseendet på sina könsorgan. Fler och fler väljer att genomgå kosmetisk kirurgi (”intimkirurgi”) trots att de befinner sig inom normalspannet. Vi startar idag en studie för att undersöka mer om detta. Vi undrar:
Hur vanligt är det att vara missnöjd med utseendet på ens vulva eller penis? Är man mer eller mindre missnöjd om man legat med många människor? Hänger det ihop med hur man faktiskt ser ut, eller om man fått negativa kommentarer från andra? Blir det så illa att man undviker att t.ex. ha sex? Och stämmer det som ofta påstås, att ens missnöje hänger ihop med hur mycket porr man tittar på?
Vi kommer undersöka detta genom en helt anonym internetenkät, där folk får svara på en rad frågor. Enkäten har idag öppnat på penisstudien.se och vulvastudien.se. Alla vuxna kan delta helt anonymt. Vi är intresserade av deltagare oavsett om du har besvär eller ej.

Can genes predict outcome in CBT?

In a new study by our group, we showed for the first time an association of a polygenetic signal and outcome in CBT. The study was published in Molecular Psychiatry and included 894 individuals with depression who underwent 12 weeks of internet based CBT. Single-nucleotide polymorphism genotyping arrays were used to calculate the genomic risk scores based on large genetic studies of six phenotypes: major depressive disorder, bipolar disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, intelligence, and educational attainment. The relationships between the six genetic risk scores and cognitive behavior therapy outcome was analyzed. Our analyses yielded one significant interaction effect (B = 0.09, p < 0.001): the autism spectrum disorder genetic risk score correlated with Montgomery Åsberg Depression Rating Scale-Self Rated changes during treatment, and the higher the autism spectrum disorder genetic load, the less the depressive symptoms decreased over time.  Our preliminary results indicated, as expected, that the genomics of the response of patients with major depression to cognitive behavior therapy were complex and that future efforts should aim to maximize sample size and limit subject heterogeneity in order to gain a better understanding of the use of genetic risk factors to predict treatment outcome.

For full text: https://www.nature.com/articles/s41380-018-0289-9

Andersson E, Crowley JJ, Lindefors N, Ljótsson B, Hedman-Lagerlöf E, Boberg J, El Alaoui S, Karlsson R, Lu Y, Mattheisen M, Kähler AK, Svanborg C, Mataix-Cols D, Mattsson S, Forsell E, Kaldo V, Schalling M, Lavebratt C, Sullivan PF, Rück C. Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report. Molecular Psychiatry. 2018

 

 

 

Funding from the Swedish Research Council

Good news! The Swedish Research Council (Vetenskapsrådet) has awarded us 2.4 million SEK over the next 3 years for our PRiMED-study (Predicting Response to CBT in Mental Disorders using multimodal data and machine learning). Bild1

Anmäl dig till vår genetikstudie

Nu är vår studie av OCD (tvångssyndrom), BDD (dysmorfofobi), samlarsyndrom och tics/Tourettes öppen för att du kan anmäla dig själv oavsett om du har tidigare diagnos eller inte. Du anmäler dig på ocdgenetik.se och svarar på frågor och får sedan ett DNA-salivkit hemskickat. Mer info på sidan.

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