PRiSMED: Predicting health and socioeconomic outcomes in patients with common psychiatric disorders

Depression, social anxiety disorder, panic disorder, and obsessive-compulsive disorder are common mental disorders with a combined point prevalence of 15%. Almost 50% of diagnoses leading to sick-leave in Sweden are psychiatric and their share is increasing. Cognitive behavior therapy (CBT) is first-line treatment for these conditions. Yet, 30-60% of patients will not respond to CBT. Coupled with advanced modeling, we could augment precision psychiatry allowing for tailored intervention and cost-effective resource use.

The project main purpose is improved outcome prediction for common mental disorders in routine clinical care. We will build prediction models for both clinical CBT outcomes (e.g., remission) and long-term outcomes (e.g., poverty) using multimodal data on 5,000 genotyped and register-linked patients treated with CBT – the hitherto largest data collection of its kind.

People involved in the project
John Wallert, psychologist, associate professor, Karolinska Institutet (KI). Role: PI. Christian Rück, psychiatrist, Professor, Research group leader, KI. Role: co-PI, patient expertise, study design. Olly Kravchenko, PhD student, Role: data management and modelling. Lorena Fernández de la Cruz, Associate Professor, KI. Role: patient risk factors and outcomes. David Mataix-Cols, psychologist, Professor, KI. Role: patient expertise, study design. James Crowley, Associate Professor, University of North Carolina – Chapel Hill (UNC-CH, USA), affiliated to KI. Role: Expert in genetics. Magnus Boman, Professor, KTH Royal Institute of Technology. Role: AI expertise. Evelyn Andersson, PhD. Role: CBT and patient knowledge. Viktor Kaldo, psychologist, Professor, Linneaus University, group leader, KI, senior advisor Internet Psychiatry Unit. Role: CBT expertise, Clinic facilitator. Cecilia Magnusson, Professor, KI, Director of the Centre for Epidemiology and Community Medicine. Role: epidemiology expertise, supervising register linkage. Patrick F Sullivan, Professor, KI and UNC-CH (USA), Founder and lead PI of the Psychiatric Genomics Consortium, KI Psychiatric Genomics Institute. Role: genetics/supervision. Julia Boberg, psychologist, PhD student. Roles: CBT and patient knowledge, data handling. Kirk Geale, health economist, MSc, Umeå University. Role: health economist involved in the planning of Aim 3. Niklas Juth, PhD, senior lecturer, Stockholm Centre for Healthcare Ethics, KI. Role: medical ethics expertise.

Group members involved in the project