Increased risk of suicide in patients with obsessive-compulsive disorder

title Fernández de la Cruz et al

In a recent study published in Molecular Psychiatry, members of our group and colleagues at Karolinska Institutet have looked at suicide in obsessive-compulsive disorder (OCD). The study compared rates of suicide among 36 788 patients with OCD and matched controls without an OCD diagnosis.

The risk of dying by suicide was found to be about 10 times higher in patients with OCD (OR = 9.83 (95% CI, 8.72-11.08). Patients with OCD were also about 5 times more likely to attempt suicide (OR = 5.45 (05% CI, 5.24-5.67). The risk was marginally attenuated in women compared to men.

Lorena Fernández de la Cruz and her co-authors also note that the increased risk of death by suicide

“… remained substantial after adjusting for different groups of psychiatric comorbidities that are already known to be associated with suicide. In fact, 43% of the individuals from the OCD cohort who died by suicide did not have any other recorded psychiatric comorbidity.” (p. 4)

They argue that OCD is associated with an increased risk of death by suicide in its own right. The main predictor for dying by suicide was a previous suicide attempt.

The message for clinicians is clear:

“OCD should be added to the list of psychiatric disorders that are known to increase the risk of suicide in their own right. Suicide risk needs to be carefully monitored in these patients, particularly in those who have previously attempted suicide.” (p. 6)

The paper is freely available here.

 

 

Kick-off meeting for Swedish OCD Genetics project at Hesselby Slott

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English summary

During March 16th & 17th, clinicians and researchers from across Sweden gathered at Hesselby Slott to facilitate the launch of a big OCD genetics project. The goal is to gather DNA from 5000 Swedish pediatric and adult patients in order to gain new insights regarding the etiology of OCD and related disorders. The event was organized by Assoc. Prof. Christian Rück & Prof. David Mataix-Cols, principal investigators in the project.

Special guest Associate Professor Jim Crowley (University of North Carolina) gave an introduction to genetic research in OCD and other psychiatric disorders. Clinicians & researchers from all over Sweden also presented their work on OCD and related disorders.

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Svenska OCD nätverksmötet 2016

16-17 mars arrangerades ett nätverksmöte för kliniker och forskare inom OCD och relaterade tillstånd. Mötet ägde rum på Hesselby Slott utanför Stockholm med docent Christian Rück och professor David Mataix-Cols som värdar.

Målet för mötet var dels att knyta nya kontakter mellan verksamma inom området och dra lärdomar av varandras arbeten. Nätverksmötet innebar också starten för en stor insamling av genetiska data för patienter med OCD och relaterade tillstånd.

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New study: internet-based treatment for BDD

We have just launched our first study of a English-language version of our BDD treatment that has been shown to be effective in Swedish studies.

It is a 12-week internet-based CBT treatment that is open for adults with Body Dysmorhic Disorder (BDD). Read more about BDD and how to register for the study at bddstudy.com.

At this time, the study is open to residents of Sweden only. We are hoping that it will open to international participants in the future.

Leder tvångstankar till mord?

Det har vid flera tillfällen på senare tid rapporterats om tvångstankar kring mordfall.

Här har vi samlat några av de artiklar i ämnet som förklarar varför detta är fel, tvångstankar/tvångssyndrom är inte förknippat med fler brott eller något känt mordfall.

http://www.sydsvenskan.se/lund/experterna-det-ror-sig-inte-om-tvangstankar/

http://www.aftonbladet.se/debatt/debattamnen/medier/article21944620.ab

En svensk studie som inte såg ökad risk för våldsbrott vid tvångssyndrom hittar du här.

New study: internet-based CBT for Body Dysmorphic Disorder

Our study comparing internet-based CBT and online support therapy for BDD has just been published in the British Medical Journal.

Enander J, Andersson E, Mataix-Cols D, Lichtenstein L, Alström K, Andersson G, Ljótsson B, Rück C. Therapist guided internet based cognitive behavioural therapy for body dysmorphic disorder: single blind randomised controlled trial. BMJ 2016;352:i241

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Ny podcast: Vad är poängen?

Christian Rück och Alex Kossek har startat en podcast som heter “Vad är poängen…?” där de med gäster talar om ämnen som sex, städning, hoarding, meningen med livet och lite annat.
http://www.vadarpoangen.se/
Podden på iTunes: https://itunes.apple.com/se/podcast/vad-ar-poangen../id1070493753?mt=2&ign-mpt=uo%3D4

Podden på Radioplay: http://radioplay.se/podcast/vad-ar-poangen

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Ny behandlingsstudie av samlarsyndrom / Hoarding

Vi genomför nu en studie med internetstödd kognitiv beteendeterapi i grupp för samlarsyndrom.

Det är vanligt att samla på sig saker men vissa personer samlar på sig så mycket att deras hem fylls upp. Personer med samlarsyndrom (Hoarding Disorder) behåller avsiktligen sina saker och kan uppleva starkt obehag när de ska göra sig av med dem.

Vid Karolinska Institutet genomförs just nu i samarbete med SLSO en studie där vi testar internetstödd kognitiv beteendeterapi i grupp för samlarsyndrom. För att delta måste du vara minst 18 år. Behandlingen sker i grupp (i Stockholm) och på Internet och förutsätter att du har tillgång till en dator.

Läs mer och anmäl dig på samlarsyndrom.se.

Rücklab visits professor Kerstin Lindblad-Toh laboratory at The Broad Institute of MIT and Harvard

Canine and murine genetics can help us get answers on human psychiatric disorders such as OCD and related disorders.

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Inspiring work of this group and impressive building.

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We are very happy to have seen the lab and the genetic chips and sequencers. We want to thank Jessica Alföldi, Group Leader, Vertebrate Genome Biology and postdoctoral researcher Hyun Ji Noh at Broad Institute for this tour!

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ICBT lecture at Cambridge by Rücklab Jesper Enander

The Rücklab Boston-tour continued on Wednesday with a new lecture on ICBT at Cambridge Health Alliance, Macht Center. The introduction by Professor Marshall Forstein, Director of the Adult Psychiatry Residency Program at the Cambridge Health Alliance/Harvard Medical School started with the question “Did anybody hear about the internet?”prof_MarshallForstein_Cam

– and Jesper Enader, psychologist and PhD student at Rücklab continued telling everybody of the evidence and possibilities of this well-known media in psychiatry.

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Many interesting discussions arouse about availability of evidence based psychiatric treatment all over the world. The technique can be translated to different languages, endlessly customised and adapted to suit children and even illiterates – the possibilities are huge and costs minimal as compared to face to face treatment. The interest from te audience was huge.

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Discussions continues over a pleasant dinner at The Harvard Faculty Club with Nina Shreshta, MD and resident in Psychiatry and James Irvin Hudson, Professor of Psychiatry, McLean Hospital.IMG_2015