Vi söker en post doc

Vill du bli post doc i vår grupp och vara med och leda en av de mest spännande studierna av psykologisk behandling? 4-dagars intensivbehandling med KBT utvecklad av Gerd Kvale och Bjarne Hansen från Bergen har fått stor uppmärksamhet och preliminära resultat ser mycket bra ut. De ser det som en helt ny sorts behandling, inte bara mer intensiv i tid. Om principen stämmer mer generellt skulle mycket ändras i hur KBT behandling ges. I Norge har det redan blivit standard för OCD. Men studien som jämför det med standardbehandling saknas. Vi vill göra den.En stor randomiserad prövning med fullt fokus på maximal kvalitet och reproducerbarhet (open science). Vill du vara med och leda den? Sök tjänsten! God finansiering, potentiell egen doktorand från start.

Läs mer och sök här: https://ki.varbi.com/what:job/jobID:419068/

Genetics of OCD

Julia Boberg – psychologist, PhD student and research group member – recently published a review article on the genetic epidemiology and molecular genetics studies of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms.

Results

OCD is a heritable, polygenic disorder with contributions from both common and rare variants, including de novo deleterious variations. Multiple studies have provided reliable support for a large additive genetic contribution to liability to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide association studies have not produced significant results yet, likely because of small sample sizes, but larger meta-analyses are forthcoming. Both twin and genome-wide studies show that OCD shares genetic risk with its comorbid conditions (e.g. Tourette syndrome and anorexia nervosa).

Conclusions

Despite significant efforts to uncover the genetic basis of OCD, the mechanistic understanding of how genetic and environmental risk factors interact and converge at the molecular level to result in OCD’s heterogeneous phenotype is still mostly unknown. Future investigations should increase ancestral genetic diversity, explore age and/or sex differ- ences in genetic risk for OCD and expand the study of pharmacogenetics, gene expression, gene × environment interactions and epigenetic mechanisms for OCD.

Read the full article here.

Om psykoterapi, pandemi och utmattning – Christian Rück gästar podden Sinnessjukt

Christian Rück – psykiatriker, professor och forskargruppsledare – gästar de senaste två avsnitten av podcasten Sinnessjukt av Christian Dahlström. I avsnitten avhandlas allt från internetpsykiatri och den brittiska IAPT-modellen till diagnosen utmattningssyndrom, kritiken mot processen bakom den samt lovande studier med KBT-behandling mot utmattning.

Dessutom får han svara på frågan vilka forskningsområden han tycker är de mest under- respektive överskattade.

Avsnitten finns att lyssna på där poddar finns, eller i webbläsaren här och här!

English translation: Christian Rück, psychiatrist, professor and research group leader, is participating in the Swedish podcast Sinnessjukt, talking about internet psychiatry, the IAPT model and the Swedish diagnosis “exhaustion disorder”.

Two new publications:

On iCBT for Symptoms of Anxiety and Depression After Myocardial Infarction, and Cognitive Dedifferentiation in Abnormal Cognitive Decline

This week, John Wallert published not one but two articles! 🎉

  1. Internet-Based Cognitive Behavioral Therapy for Patients Reporting Symptoms of Anxiety and Depression After Myocardial Infarction: U-CARE Heart Randomized Controlled Trial Twelve-Month Follow-up

    The aim of this study was to evaluate the long-term effectiveness of internet-based cognitive behavioral therapy on self-reported symptoms of anxiety and depression in patients 12 months after a myocardial infarction and to explore subsequent occurrences of cardiovascular disease events. Shortly after acute myocardial infarction, 239 patients reporting mild-to-moderate symptoms of anxiety or depression were randomized to 14 weeks of therapist-guided internet-based cognitive behavioral therapy (n=117) or treatment as usual (n=122). 

    The study’s conclusions was that internet-based cognitive behavioral therapy was not superior in reducing self-reported symptoms of depression or anxiety compared to treatment as usual at the 1-year follow-up after myocardial infarction. A reduction in cardiac-related anxiety was observed but was not significant after adjusting for multiple comparisons. There was no difference in risk of cardiovascular events between the treatment groups. Low treatment adherence, which might have affected treatment engagement and outcomes, should be considered when interpreting these results.

  2. Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts

    The cause of cognitive dedifferentiation has been suggested as specific to late-life abnormal cognitive decline rather than a general feature of aging. This hypothesis was tested in two large cohorts with different characteristics. The subjects came from two research databases in North America and Sweden. Dedifferentiation was explained by cognitive impairment when controlling for age, sex, and education. This finding replicated across two separate, large cohorts of older individuals. Knowledge that the structure of human cognition becomes less diversified and more dependent on general intelligence as a function of cognitive impairment should inform clinical assessment and care for these patients as their neurodegeneration progresses.

Elin Lindsäter i Stressforskningspodden

Elin Lindsäter medverkar i senaste avsnittet av Stressforskningspodden där hon pratar om psykologisk behandling av stressrelaterade sjukdomar. Deltar gör även Margot Hinzdahl, som fått behandling i en av Elin studier, och filmskaparen Ruben Östlund som pratar om hur psykologisk behandling gestaltas på film. Lyssna här eller i din podd-app.

Elin är psykolog och medicine doktor i forskningsgruppen och arbetar på Gustavsbergs vårdcentral. Hennes forskningsintresse rör framförallt de stressrelaterade sjukdomarna anpassningsstörning och utmattningssyndrom, för vilka det vetenskapliga underlaget för behandlingsrekommendationer fortfarande är bristfälligt och det saknas evidensbaserade behandlingar.

Stressforskningspodden ges ut från Stressforskningsinstitutet vid Stockholms universitet.

English translation: Elin Lindsäter, psychologist and PhD, visits the podcast Stressforskningspodden and talks about psychological treatment for stress-related disorders.

Mia Asplund receives grant

Mia Asplund’s research project about internet treatment for trichotillomania and dermatillomania receives a grant of 100 000 SEK from Fonden för Psykisk Hälsa (Mental Health Fund).

Trichotillomania and dermatillomania are two syndroms characterized by an excessive picking of hair or skin and is related to obsessive-compulsive disorder (OCD) among others.

Currently, the project is collecting data for follow-up for the pilot study. The succeeding RCT is being planned and will hopefully start in the fourth quarter of 2021.

Congratulations!

Ögat på stressforskning: från forskning till praktik

Välkommen till Stockholm Stress Collaboratives digitala konferens fredag 16 april 2021, kl. 8.45 – 15.30.

Konferensen ger en inblick i det senaste inom stressforskningen. Det blir en dag med intressanta forskningsöversikter och panelsamtal med experter inom området.

Se hela konferensen live här.
Tryck här för program.

Dela/sprid gärna informationen i ditt nätverk.

Varmt välkomna önskar, 

Stockholm Stress Collaborative
Julia Åhlin
Elin Lindsäter
Frank Svärdman
Shireen Sindi

English translation: Stockholm Stress Collaborative is inviting to a live streamed conference about the latest in stress research. The conference is april 16 and will be held i Swedish.

Mia Asplund i OCD-podden

Mia Asplund är med i senaste avsnittet av OCD-podden och talar om trichotillomani och dermatillomani. Lyssna här!

Mia är leg. psykolog och doktorand i forskargruppen. Hennes forskning handlar om psykologisk behandling av trichotillomani och dermatillomani, även kallat skin-picking disorder. Tricho- och dermatillomani är två psykiatriska tillstånd som innebär ett tvångsmässigt plockande av hår- respektive hud.

English translation: Mia Asplund, psychologist and and PhD student, talks about trichotillomania and skin-picking disorder in the Swedish podcast OCD-podden.

Anmälan till studie om internet-KBT mot stress

Edit: Många har anmält sig och tyvärr finns inga platser kvar till den behandlingsomgång som startar under våren. Till hösten drar vi igång igen och öppnar upp anmälningsfunktionen för flera nya behandlingsomgångar.

http://stressad.nu/ är anmälan till Elin Lindsäters studie om internet-KBT nu öppen.

English translation: Elin Lindsäter’s study about internet CBT for stress has now opened its registration.

Recruitment completed

We have now completed the recruitment for the MiO study about intestinal flora and OCD!

The study investigates if the intestinal flora is different for people with obsessive compulsive disorder. In total 62 participants were included, 30 with OCD and 32 age and gender-matched controls.

We hope to get the results in the beginning of 2022.

http://www.inasakvareller.se/