‘Game-Changing’ Depression Study Discovers 44 Genes

Skärmavbild 2018-05-03 kl. 22.04.39


We are proud that a landmark study of depression genetics published in Nature Genetics has Professor Manuel Mattheisen as one of the lead authors. Manuel is a Professor at Würzburg University but also affiliated to our group at Karolinska Institutet.

The authors conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.

Here is a commentary in The Guardian.

Nature Genetics volume 50pages 668–681 (2018)

Full paper: https://www.nature.com/articles/s41588-018-0090-3