Jim Crowley affiliated to our group

Assistant Professor James J. Crowley is now affilated to Karolinska Institutet and our group. Jim is currently at the Department of Genetics at the University of North Carolina at Chapel Hill. Check out some his recent publications here. We are very proud to have him at KI.

Evelyn Andersson sucessfully passed her half-time seminar

Evelyn Andersson a week ago passed her half time seminar with flying coulors. We wish to thank the board: Prof Jerker Hetta, Prof Bo Melin and Assoc Prof Patrik Magnusson. The PhD is on genetics and CBT.

Evelyn Andersson at her half-time seminar
Evelyn Andersson at her half-time seminar

Half-time seminar

PosterEvelyn Andersson will have her half-time seminar for her PhD (“From DNA to Therapy – Predictors, Candidate Genes and a Gene x Environment study with national register data”) on March 28 at 2 pm at Askö, M57, Karolinska Huddinge.

New study: genetic variants in the monoamine system and CBT outcome in social phobia

In a collaboration between Karolinska Institutet and Uppsala University, we studied three genetic polymorphisms in the monoamine system (5-HTTLPR, COMT val158met, TPH2 G-703T) and outcome of cognitive behavioral therapy (CBT) in social anxiety disorder (SAD) in over 300 patients. This is one of the largest genetic studies ever made on adults with SAD and CBT outcome. Monoamine-related gene polymorphisms have previously been tied to amygdala reactivity, treatment efficacy and fear extinction processes and was hereby reasoned to influence the outcome of CBT. However, none of our polymorphisms were associated with CBT outcome at long term follow-up. In our subsamples we found contradictory significant effects immediately after treatment. Even though CBT is an effective treatment of anxiety disorders, many patients (25-50%) do not respond sufficiently. Therefore, there is a need to improve not only the treatments but also how patients are selected for treatment in order to optimize the efficacy. Therapygenetics attempts to explore the relationship between genetic variation and psychological treatment response. Ultimately, such knowledge could be used to tailor therapies based on patients’ biological markers, which in turn, could improve therapeutic outcome.

Lead author Evelyn Andersson.