New publication: Internetbased CBT for teenagers with OCD

First author Fabian Lenhard
First author Fabian Lenhard.

A study published in PloS ONE tested a new ICBT platform. Twenty-one adolescents (12–17 years) with OCD and their parents were enrolled in the study. All participants received 12 weeks of ICBT with therapist support. Treatment yielded significant improvements with a large effect size of d = 2.29 (95% CI 1.5–3.07) on the CY-BOCS. Patients continued to improve at follow-up. This is a study out of Eva Serlachius’ research group at Karolinska Institutet. Click reference for full text.

Lenhard F, Vigerland S, Andersson E, Rück C, Mataix-Cols D, et al. (2014) Internet-Delivered Cognitive Behavior Therapy for Adolescents with Obsessive-Compulsive Disorder: An Open Trial. PLoS ONE 9(6): e100773. doi:10.1371/journal.pone.0100773


BDD Master Class with Sabine Wilhelm

Karolinska OCD Master Class

The Center for Psychiatry Research arranges a full-day Master Class on CBT for Body Dysmorphic Disorder (BDD) with Professor Sabine Wilhelm of Harvard University. This Master Class requires that you already are familiar with the basics of CBT.

When? September 18, 09:00-16:00

Where? Karolinska University Hospital Huddinge (Sweden).

How to register: Click here.  Limited number of attendees,

Evelyn Andersson sucessfully passed her half-time seminar

Evelyn Andersson a week ago passed her half time seminar with flying coulors. We wish to thank the board: Prof Jerker Hetta, Prof Bo Melin and Assoc Prof Patrik Magnusson. The PhD is on genetics and CBT.

Evelyn Andersson at her half-time seminar
Evelyn Andersson at her half-time seminar

New study: genetic variants in the monoamine system and CBT outcome in social phobia

In a collaboration between Karolinska Institutet and Uppsala University, we studied three genetic polymorphisms in the monoamine system (5-HTTLPR, COMT val158met, TPH2 G-703T) and outcome of cognitive behavioral therapy (CBT) in social anxiety disorder (SAD) in over 300 patients. This is one of the largest genetic studies ever made on adults with SAD and CBT outcome. Monoamine-related gene polymorphisms have previously been tied to amygdala reactivity, treatment efficacy and fear extinction processes and was hereby reasoned to influence the outcome of CBT. However, none of our polymorphisms were associated with CBT outcome at long term follow-up. In our subsamples we found contradictory significant effects immediately after treatment. Even though CBT is an effective treatment of anxiety disorders, many patients (25-50%) do not respond sufficiently. Therefore, there is a need to improve not only the treatments but also how patients are selected for treatment in order to optimize the efficacy. Therapygenetics attempts to explore the relationship between genetic variation and psychological treatment response. Ultimately, such knowledge could be used to tailor therapies based on patients’ biological markers, which in turn, could improve therapeutic outcome.

Lead author Evelyn Andersson.

New study out: mediators of change in CBT for health anxiety

A new study is out with lead author Erik Hedman. If you wonder why we call him “pekmaskinen” (Swedish for “the manuscript machine”, check Pubmed.

The study is the first to investigate mechanisms of improvement in Internet-based cognitive behaviour therapy (CBT) for severe health anxiety. We assessed mediators as well as outcome on a weekly basis throughout treatment among participants receiving Internet-based CBT in a randomized controlled trial. The results showed that reduced perceived risk of disease, less attention to bodily symptoms, and reduced intolerance of uncertainty significantly mediated improvement in health anxiety.The findings have theoretical and clinical implications as they indicate processes that may be causally related to the improvements observed after CBT for health anxiety.

Click the link for the full text:

Hedman E, Andersson E, Andersson G, Lindefors N, Lekander M, Rück C, Ljótsson B. (2013) Mediators in Internet-Based Cognitive Behavior Therapy for Severe Health Anxiety. PLoS ONE 8(10): e77752. doi:10.1371/journal.pone.0077752

Erik "Pekmaskinen" Hedman, PhD.
Erik “Pekmaskinen” Hedman, PhD.