New publication: Internetbased CBT for teenagers with OCD

First author Fabian Lenhard
First author Fabian Lenhard.

A study published in PloS ONE tested a new ICBT platform. Twenty-one adolescents (12–17 years) with OCD and their parents were enrolled in the study. All participants received 12 weeks of ICBT with therapist support. Treatment yielded significant improvements with a large effect size of d = 2.29 (95% CI 1.5–3.07) on the CY-BOCS. Patients continued to improve at follow-up. This is a study out of Eva Serlachius’ research group at Karolinska Institutet. Click reference for full text.

Lenhard F, Vigerland S, Andersson E, Rück C, Mataix-Cols D, et al. (2014) Internet-Delivered Cognitive Behavior Therapy for Adolescents with Obsessive-Compulsive Disorder: An Open Trial. PLoS ONE 9(6): e100773. doi:10.1371/journal.pone.0100773


Grants from the Swedish Society of Medicine

We are happy announce that the Swedish Society of Medicine (Stiftelsen Söderström-Königska sjukhemmet) has given us two grants of 200000 SEK each for internetbased-CBT in BDD (dysmorphofobia) and DBS in OCD (with Diana Djurfeldt as PI), respectively.

Interesting Karolinska OCD Master Class coming up: The neurobiology of fear learning and extinction

Kerry ResslerOn December 2nd:  a workshop by Prof Kerry Ressler, Emory University on the neurobiology of fear learning and extinction, including
1) Current psychotherapy and pharmacology treatment approaches to OCD
2) Translational human research on extinction processes to understanding CBT
3) Mouse behavioral/genetic research approaches to OCD and Extinction
4) Molecular neurobiology of extinction and future directions to enhancing treatment and CBT

More info and how to register at:

Winners of our first Student Award are…

We had two great nominations and choosing the winner was hard, in fact so hard that we had to find an additional extrernal reviewer to make the descision.

The winners are:

Gustaf Brander and Per Söderholm, graduates of Stockholm University for their Master Thesis: “Tilläggsbehandling som återfallsprevention efter internetadministrerad KBT vid tvångssyndrom- en randomiserad kontrollerad studie” (Adding a booster to internetbased CBT – a RCT). Supervisor: Jan Bergström.

The runners-up:

Henrik Engelmark and Niclas Stagnér, graduates of Uppsala University. Master Thesis: “Exponering med responsprevention för tvångssyndrom i ett kliniskt sammanhang – en behandlingsutvärdering på OCD-Centret i Uppsala”. (ERP for OCD – evaluated in a clinical setting”. Supervisors: Timo Hursti and Sandra Bates.

We wish to thank our review board (David Mataix-Cols, Tord Ivarsson and Susanne Bejerot).

Per Söderholm and Gustaf Brander.
Did we really win? Per Söderholm and Gustaf Brander.

OMG: Student Award, the reviews are in, it is a tie!

The two nominations for our Student Award have been reviewed by Professors Mataix-Cols and Ivarsson and the result is: 1-1! In hindsight maybe not such a clever idea to have an even number of reviewers… Anyway, the nominations are now reviewed by a third reviewer and the final result will be presented tomorrow.

Nominations for the 2013 Rücklab Student Award

2 strong nominations for our student award are in and currently the external reviewers are evaluating the proposals. The reviewers are Professor David Mataix-Cols (just moved from KCL to KI) and Assoc Professor Tord Ivarsson, University of Gothenburg  and R-BUP Öst og Sör. The nominees are:

  • Gustaf Brander and Per Söderholm, graduates of Stockholm University.
  • Henrik Engelmark and Niclas Stagnér, graduates of Uppsala University.

The winners will be presented on this webpage in due time.

New study out on Hoarding in adolescence!

The first study to present the prevalence comorbidity and heritability of hoarding in adolescents just came out in PLoS ONE. In this study, we report that 2% of Swedish 15-year olds report symptoms of hoarding including distress and/or impairment. This is quite surprising given that hoarding is considered to be a problem most common among the elderly. We also found that hoarding seldom co-occurs with OCD which supports the status of Hoarding Disorder, which has been separated from Obsessive-Compulsive Disorder in the new DSM-5. Finally, using the twin design we were able to conclude that hoarding symptoms are heritable during adolescence but only in boys. In girls, the environment, both the shared, and non-shared between twins accounted for the variability in hoarding symptoms.

Our research group has been collaborating with the Swedish Twin Registry and Professor David Mataix-Cols on this paper and this partnership is only at its start. Keep following us to see what the incredible Swedish Twin data will tell us in the future!

Ivanov VZ, Mataix-Cols D, Serlachius E, Lichtenstein P, Anckarsäter H, Chang Z, Hellner Gumpert C, Lundström S, Långström N, Rück C. (2013) Prevalence, Comorbidity and Heritability of Hoarding Symptoms in Adolescence: A Population Based Twin Study in 15-Year Olds. PLoS ONE 8(7): e69140.

The Bror Gadelius memorial fund awards Erik Andersson grant

Erik Andersson has been awarded a grant from the Bror Gadelius memorial fund for our D-cycloserine study in OCD. Who was Bror Gadelius? Well, for someone working on a thesis on OCD like Erik Andersson it is interesting to know that Bror Gadelius, once a leading Swedish psychiatrist born in 1862 wrote his thesis on obsessions (Om Tvångstankar och dermed beslägtade fenomen) in 1896. Gadelius became a professor at Karolinska Institutet in 1903 and worked hard to reform mental health care including bringing psychiatric wards to the main hospitals instead of more remote asylums.