Research on OCD and related disorders, precision psychiatry, psychiatric genetics, suicide prevention, stress and PTSD
Ekaterina Ivanova has received not one but TWO grants from Swedish Society of Medicine (Svenska Läkaresällskapet), the post doc grant and the project grant.
Both of the grants are for the Bergen 4 Day treatment project, an RCT testing the non-inferiority, speed of recovery, and cost-effectiveness of Bergen 4-Day Treatment (B4DT) for obsessive compulsive disorder (OCD), compared to gold-standard CBT.
Read more about the Bergen 4 Day treatment-project here.
Congratulations Katja! 🎺🎺🎺
Happy New Year!
The article Does Size Matter? Genital Self-Image, Genital Size, Pornography Use and Openness Toward Cosmetic Genital Surgery in 3503 Swedish Men and Women has been selected the best surgery paper 2022 in The Journal of Sexual Medicine!
Jesper Enander, Ekaterina Ivanova and Christian Rück from the group have been working on the paper together with Ingvill Baghøien Hosted and Karin Malmqvist.
How honorable!
We have received $1,494,898 from the American Foundation for Suicide Prevention (AFSP) for the Saving Lives project!
The project aims to improve precision in prediction and prevention of suicide by constructing a national cohort of genetic and environmental data. The ultimate goal is to decrease suicide rates.
Suicide is a tragic event for the individual, the relatives and society. We therefore make efforts to prevent suicide, and a typical way of doing this is to assess suicide risk. Still, studies in psychiatric populations show that current assessments available will classify one out of two suicidal individuals as low risk before an actual death by suicide, while 95% of those classified as high risk will eventually not die by suicide.
Why?
The causes of suicide are complex. Many different factors and life events contribute. To improve prediction, large studies and long follow-up are needed to reach meaningful sample sizes.
Using unique Swedish assets, of genetic and environmental data, and machine learning we have an opportunity a discover environmental and genetic risk factors associated with suicide in order to predict and prevent it.
We thank the AFSP for this grant.
Vi har just öppnat anmälan till en studie som jämför två olika behandlingsformer för personer med tvångssyndrom.
Läs mer och anmäl dig här: www.ocdprojektet.se
Kognitiv beteendeterapi (KBT) har visat sig vara effektivt för att lindra både tvångstankar och tvångshandlingar när den genomförs under 14 veckor. Karolinska Institutet och Region Stockholm genomför nu en studie som jämför denna typ av KBT med en intensivbehandling som pågår i 4 heldagar.
Mer information
English translation: We have opened the registration for an RCT comparing a new concentrated treatment for OCD to golden standard CBT.
We are looking for a new doctoral student to join our computational team!
Do you want to contribute to top quality medical research?
In the research group we work to improve the lives of individuals with psychiatric conditions. A core theme of our research is to develop more accurate prediction models for both the risk of, and also consequences of, psychiatric conditions.
The main scientific objective of your PhD project is to advance knowledge in suicide prediction. Suicide is a catastrophic event for the individual, close relatives, colleagues, and society. Your project is focused on statistical modelling in two different studies. In both studies you will collaborate with colleagues at Oxford University (UK), University of North Carolina Chapel Hill (US) and Sweden.
🎯Research project 1 is a registry study of risk factors for suicide among psychiatric patients that have experienced compulsive mental care.
🎯Research project 2 you will be working with multimodal data (including genetic data) in a nationwide suicide cohort with the purpose of improving present prediction of suicide aiming to derive and validate better risk models for suicide in the total population.
The position is a part of the Rücklab computational team, led by John Wallert.
We look forward to receiving your application!
Mia Asplund et al have looked into the feasibility of internet-delivered acceptance based behavioral therapy (BT) for trichotillomania (TTM) and skin-picking disorder (SPD).
Click here to read the article.
Short summary:
25 clinical-referred patients with TTM and SPD underwent internet-delivered BT for 10 weeks. The treatment involved both traditional interventions such as habit reversal and more acceptance based strategies.
A majority of the participants were satisfied with the treatment and found it credible. Hair pulling and skin picking severity decreased significantly from pretreatment to posttreatment, and most outcome measures remained significant at the 12-month follow-up.
Taken together, he results provide initial evidence suggesting that I-BT could be a feasible, acceptable and potentially effective treatment for TTM and SPD.
👏👏👏👏
The registration is now open for our study investigating the feasibility of internet-delivered prolonged exposure for patients with post-traumatic stress disorder (PTSD).
Psychological treatments, commonly using trauma focused cognitive-behavioral techniques, like prolonged exposure (PE) are today recommended as first-line treatments for PTSD. Unfortunately, this treatment is not available to everyone who needs it. Therefore, we are investigating the feasibility of internet-delivered prolonged exposure for patients with PTSD.
Primal investigator of the project is Maria Bragesjö.
Oroar du dig väldigt mycket över din hälsa?
Vill du på egen hand jobba med ett digitalt verktyg för att hitta sätt att hantera den här oron?
Karolinska Institutet undersöker just nu om ett digitalt egenvårdsprogram kan hjälpa personer som besväras av hälsoångest.
Med hälsoångest menas:
Studien pågår under 8 veckor och sker helt via dator/smartphone. Deltagare över 18 år från hela landet är välkomna att anmäla sig.
Läs mer / gör intresseanmälan på: https://egenvard.webcbt.se/registration/16644
Kontakt:
Projektledare: Susanna Österman, leg psykolog och doktorand
susanna.osterman@ki.se, 0708842418
Ansvarig forskare: Martin Kraepelien, leg psykolog och med dr.
martin.kraepelien@rucklab
English translation: We are now including participants for a study testing a digital self-care program for people suffering from health anxiety. Project manager is Susanna Österman, PhD student in our research group.
The article Predicting remission after internet-delivered psychotherapy in patients with depression using machine learning and multi-modal data is now published in Translational Psychiatry and ready to be read and spread.
The study applied supervised machine learning with multi-modal data to predict remission of major depressive disorder after internet-delivered psychotherapy. Predictor types were demographic, clinical, process, and genetic and outcome was remission status post ICBT. Transparency analysis showed model usage of all predictor types at both the group and individual patient level. Future iterations of the derived and validated model may inform tailored intervention before initiating ICBT for MDD. The multi-modal approach to predict remission in these patients holds promise and warrants further investigation to establish clinical utility.
The authors are John Wallert, Julia Boberg, Viktor Kaldo, David Mataix-Cols, Oskar Flygare, James Crowley, Matthew Halvorsen, Fehmi Ben Abdesslem, Magnus Boman, Evelyn Andersson, Nils Hentati Isacsson, Ekaterina Ivanova and Christian Rück.
Edit: Anmälan är stängd på grund av ett stort antal anmälningar på kort tid/The registration is closed due to a large number of applicants.
Nu drar Rücklab igång rekryteringen till en kontrollerad studie där vi testar effekten av internetförmedlad KBT för dermatillomani jämfört med väntelista. Behandlingen, som är kostnadsfri, pågår under 10 veckor och sker på distans via en säker internetplattform. Kontakt med behandlare sker via textmeddelanden.
Alla som deltar i studien erbjuds behandling. Man måste vara minst 18 år för att delta och boende i Sverige.
Kontakta gärna projektledande psykolog Mia Asplund om du har frågor kring studien! E-post: mia.asplund@ki.se
Vad är dermatillomani?
Dermatillomani eller skin-picking disorder som det kallas på engelska, innebär ett överdrivet plockande, pillande eller klämmande på huden. Ofta plockar man i ansiktet, på armar och händer, men många plockar även hud från andra ställen på kroppen. Det vanligaste är att man söker efter ojämnheter som pormaskar, finnar, hudflikar, förhårdnader, sår eller sårskorpor från tidigare rivande
Hudplockandet kan triggas av ett inre sug, och för vissa leda till en känsla av lättnad eller tillfredställelse. Andras plockande triggas av rastlöshet eller jobbiga känslor som stress och oro och upplever att plockandet hjälper till att lindra dessa negativa känslor.
English translation: The registration is now open for a controlled study testing internet-delivered CBT for dermatillomania (also known as skin-picking disorder). Contact psychologist and project manager Mia Asplund if you have questions about the study. Edit: The registration is now closed.
Rücklab - Psychiatry research at Karolinska Institutet 